Impact investing is gaining traction and believers

By Maureen Aylward

One of the fastest growing asset classes in institutional investing is impact investing. We asked our Zintro experts to tell us what they see as the real potential of impact investing.

Gordon Upton, an expert with 30 years experience in corporate and project finance, impact investment, and venture and capital markets, says that the challenge facing impact investment right now, despite growth in the supply of impact investment capital and the increased demand for it, is that there is only a trickle of capital flowing from investors to actual projects. “Established financial services providers generally believe that all capital should either be invested to maximize profits, with little or no regard for social or environmental effects, or simply donated to charity to maximize social or environmental returns. These beliefs do not serve impact investors,” says Upton.

Upton points out that the absence of effective market mechanisms, such as market clearinghouses, rating agencies, and syndication facilities seriously hamper investment. “On the supply side, high sourcing costs and lack of information, especially on social returns, leave potential impact investors wary of entering the field,” he says. “On the demand side, fragmentation of investment supply together with the inability to syndicate start-up and expansion finance opportunities, sets off an inefficient capital sourcing process that stifles the launch and expansion of new projects.”

The opportunity is to build a system that will allow impact investment to flow into broader areas of public interest, such as agriculture, provision for basic services, energy, housing, and healthcare in emerging markets. This will enable the impact investment movement to expand opportunities and ensure the shared benefits of globalization. “Impact investment can create and maximize value by blending corporate social responsibility, social enterprise, social investing, strategic and effective philanthropy, and sustainable development while addressing the cross-cutting issues of capital, performance metrics, leadership, organizational development, public policy, and tax and regulatory questions,” explains Upton.

Bulankov, a financial advisor and planner in investment and asset management, says certain investment strategies that were once the exclusive prerogative of select ultra-high-net-worth families and institutions are now making their way to Main Street. “Nowadays, most any investor with as little as $5,000 can establish a philanthropic fund through a donor- advised vehicle, invest in a socially responsible way, or provide micro-loans through the internet,” he says. For those not content with purely philanthropic pursuits, impact investing is the next logical step in this evolution.

“Voting with your wallet is taking a whole new, quite literal meaning,” Bulankov says. “It is only logical that an area that allows investors to align their values and desires for good with their desires for gain is one of the fastest growing areas.” He believes that impact investing gives the investor an avenue to lobby and further the cause that the investor deems worthy by putting money behind that cause, knowing that the full investment due diligence and analysis has been performed and there is no need to sacrifice gain to do good. “In my opinion, this is a very strong driving force behind impact investing, a force that may propel the industry to grow tenfold over the next decade,” Bulankov predicts.

What do you think? If you have a question or comment about the impact investment sector, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

Zintro experts outline top picks for optical engineering and photonics innovation

By Maureen Aylward

The fields of optical engineering and photonics cover so many ideas, projects, and applications. We wanted to hear from our Zintro experts about their top picks for the most innovative ideas, research, or applications.

John Sugrim, an electro-optical engineer, says his top pick for innovation in optical engineering is the use of lasers in the medical field, specifically using lasers with optical fibers to deliver optical radiation for specific purpose. “One of the most exciting developments I have seen is using fibers to deliver UV radiation to a catheter that is implanted in the human body,” says Sugrim. “Running this leaky fiber in the catheter with UV radiation sterilizes the device in situ. Another major impact is photoactivation of a drug that is delivered to the human body.”

Another top pick of Sugrim’s is the use laser for spectroscopy. “Lasers of a certain frequency can pick out a needle in a haystack quickly,” he says. “The key point of saturation spectroscopy is that laser frequency has to be resonant with the particulate you are looking for.” Sugrim says this technology is in use in detecting chemical and biological agents in the atmosphere and for genome sequencing.

Sugrim’s third pick is the actual development of lasers. “We have seen development in the smaller wavelength laser, pushing into the deep UV regions and the long IR. Both of these directions are important to further the development of the technology,” he says. “For instance, in deep UV lasers, this will allow production of smaller transistors because these lasers use the photo lithography process. In the long IR case, these lasers are used for hard tissue ablation, such as for a drill-less root canal.”

Luis Figueroa, a technical domain expert in photonics, communications, networking and electromagnetic technologies, says that silicon based photonics (integrating IC technology with optoelectronic devices on a Si substrate) is making significant research advances. “It offers the potential for monolithic integration of Si IC technology with Si-based optoelectronic devices for the creation of a new generation of communication and computing interconnects,” says Figueroa. “The future of Si photonic integrated circuits (PICs) will be built with higher complexity and reduced cost, and significantly reduced power/bit data. A few companies have fully integrated silicon photonics technology for transceivers that are used in short and medium range optical interconnects in data centers and supercomputers.”

Figueroa says that nanotechnology offers the potential for creating photonics crystals and meta-materials for tailoring the optical properties of structures over a range of frequency bands and the creation of ultra-sensitive detectors; for example, in detecting trace amounts of explosives and very high speed optical and ultra-linear modulators for high performance RF analog links.

“Dense Wavelength Division Multiplexing (DWDM), an optical multiplexing technology used to increase bandwidth over existing fiber networks, is continuing to advance at a rapid rate and offers the ultimate potential for cloud computing with broadband access at any location,” says Figueroa. “Without DWDM, Web 2.0 and cloud computing would probably not exist in its present form. In the area of laser communications, DWDM technology offers the potential for Terabits/s communication pipes and the integration of satellite, aircraft, and ground links. Lastly, the technology offers the potential to revolutionize military systems by significantly reducing the wiring complexity and, at the same time, increase the bandwidth throughput for handling the exponentially increasing data loads.”

What do you think? If you have a question or comment about the optical engineering or photonics industry, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

Geomatics and geospatial technology rolls with the changes

By Maureen Aylward

If it’s true what they say about technology exponentially changing every two years, then the geomatics and geospatial technology may be in the running for some major changes. We asked our Zintro experts to discuss what ahead for this innovative industry.

Dr. Helmi Al Jamal, a subsea engineer and analyst, says that the majority of new oil and gas potential explorations are directed towards deeper waters in the global oceans. “Challenging locations require specific measuring and surveying tools to locate oil and gas reservoirs, which involves advancements in geo-sciences,” he says. “The dependency on geomatics and geospatial sciences will be exceptional in the coming few years because the need for energy is exponentially escalating, which reflects the same escalation trend of all technologies in relation to energy.”

Dr. Al Jamal says that although deepwater field development operations became highly restricted after the BP oil spill in April 2010, major oil/gas production companies have put advanced development programs into place and allocated funding to explore oil into even deeper waters. This potential interest requires an expedited advancement in geo-sciences to allocate potential oil spots, no matter how deep these spots are.

Satya, a chief technology officer, says that the applicability of geospatial technology is vast and it is a horizontal one that supports all verticals. It looks as if the geospatial technology can be adapted based on other changes ongoing in different sectors of technology. “For example, the banking industry is one of the largest domains to use geospatial technology for ATM and branch locations,” says Satya. “When banking moved to mobile, the current hot technology, features like the ATM and branch locator also moved mobile.”

What do you think? If you have a question or comment about the geomatics or geospatial industry, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

Will China’s dominance of the rare earth elements market affect supply?

By Maureen Aylward

With global use of rare earth elements growing, we asked our Zintro African Business experts to provide their opinions on how access to these raw materials can diversify.

Michael Keating, a renowned international risk management consultant and specialist in media, development and business in Africa, says that the rare earth market needs to diversify because of China’s dominance and the country’s ability to manipulate world supply through its export practices. “While it is unlikely that China will cut off supply to existing trading partners, there is certainly opportunity for price-fixing and favoritism,” says Keating. “China will likely try to corner the market in other mining zones, but the West can make a difference by cutting deals and managing projects that are scaled correctly and take account of China’s weaknesses in how it manages developing world investments.”

Keating says the mining of rare earth elements needs to expand into friendly or neutral zones, such as Africa and Central Asia, and safe sites in Canada and Australia. “African mining, which I am most familiar with, has enormous upside potential for firms that are savvy and know how to manage risks,” says Keating.

Michael Rada, a professional with expertise in raw materials management, says the main issue in rare earth elements is the limitation of their presence and knowledge of where these elements exist in other areas of the world. “There needs to be a diversification approach,” says Rada, “so that there is enough choice for the most efficient supply to local and international clients.” Rada would like to see more attention paid to avoiding the use of and reducing dependence on rare earth elements. “There should be more time and money invested in finding alternative solutions before the rare earth elements are exploited,” he says. “There should be cooperative action and synergy to get the right solution before these materials are depleted.”

What do you think? If you have a question or comment about the mining industry, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

Hydraulic fracturing or fracking: Raising health and safety concerns

By Maureen Aylward

Hydraulic fracturing or fracking, the most widely used drilling method to extract methane from shale beds, is under pressure because of safety and health concerns. We asked our Zintro experts about the issues surrounding this extraction method and how it impacts human health and the environment.

GeoFuture, an expert in the oil and gas industry, says that hydraulic fracturing is the preferred industry method for hydrocarbon resource extraction and controlled recovery, which is performed during the completion processes of drilled methane (natural gas) wells. “Common fracturing practices at the surface of the wellbore include the introduction of forced high pressure fluid, typically a proprietary mixture, primarily made up of water; proppant, which is sand or synthetic bead; and compressed inert gas, commonly nitrogen, carbon dioxide, and/or air,” GeoFuture explains. “Fracturing is a proven method to effectively increase the potential volumetric production capability and sustainability of a drilled well by influencing the underground source rock to release the methane trapped within. Fracturing is highly regarded as a safe and well planned procedure among the production fleet, but it seems recent activity has stirred up controversy.”

The recent public interest concerning the possibility of health and safety risks as a byproduct of fracturing have drawn the attention of the news media. “Past incidents like the Deepwater Horizon blowout in the Gulf of Mexico and the Exxon Valdez in Alaska have contributed to this public interest in fracturing and raises concern for the oil and gas industry to develop and implement stricter standards regarding operations that may pose a viable threat to the surrounding areas of drilling, production, and transportation,” says GeoFuture. “Fracturing has led to reports of contamination near existing oil and gas wells, so there has been a focus on the possibility that it could contribute to groundwater and agricultural contamination. Much of the public outcry and concern is legitimate, yet fault and responsibility claims are unsubstantiated due to a large amount of speculation along with a lack of conclusive evidence to support claims that fracturing is the culprit.”

GeoFuture points out that EPA case studies document a few exposures in Pennsylvania over the last five years, showing that groundwater contamination took place in the immediate vicinity of existing wells dating back decades. “It seems these older wells were of little concern with regard to contamination activity until new drilling activity began nearby,” he says. “Some sources have claimed fracturing the modern wells may have led to underground damage to the antiquated equipment of the older wells merely by the relationship of proximity. However improbable or unlikely as these claims may be, it is still a questionable matter. Ultimately, the hypothetical result of fracturing lends itself to review of an older well’s integrity and infrastructure by inflicting over-pressure and shock.”

GeoFuture says the current debate represents an excellent requirement for due diligence based fundamentally on the possibility that some form of health, safety, and/or environment may be at risk. “I feel strongly that the benefits are tremendous and vast as consumption necessity demands, but the relationship between the consumer and the provider must always maintain that of a symbiotic state,” he says. “For that mutually beneficial balance to continue, proactive measures must be taken by both sides to further investigate possible negative impacts relevant to fracturing. If discrepancies are discovered, operators must immediately address the requirement for a solution.”

Enrico Saperdi, an oil and gas industry professional, says that there are various issues about hydraulic fracturing for shale gas exploration and production. He says that the industry needs to address the same issues that are present when drilling a conventional gas well and tackle specific questions related to:

  • Types of chemicals used for fracturing (Are they safe, toxic?),
  • Possible contamination of shallow groundwater, and
  • Release of methane into the air (If the quantity is high, it can contribute to the greenhouse effect).

“The potential concerns are currently addressed by various studies, such as the one by the EPA in US,” says Saperdi. “I believe that the technology and knowledge to operate with an acceptable impact on environment already exists, but risks need to be identified and managed case by case from the beginning of any project.”

What do you think? If you have a question or comment about the oil and gas industry, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

What are experts in DNA/RNA/Cloning thinking about?

By Maureen Aylward

We asked our Zintro experts about the most recent DNA/RNA/Cloning research and where it might be heading. We were also curious about how the research is being successfully applied. Here is what our experts had to say.

Radoslav Bozov, founder of the theory of carbon signaling, explains that cloning research was initiated as a field of biological science when Dolly was successfully cloned via transferring a nucleus from a mammary gland cell substituting an egg cytoplasm. “It is important that one understand how protein interferes with genome expression as the nucleus has a vast array of so-called transcription factors eliciting response towards expression of a particular piece of genomic information,” says Bozov.

“Cloning technology has high ethical issues as organisms may be cloned and used for organ replacement,” explains Bozov. “Thus, the scientific community is divided into ones that do not support whole organism cloning and others that do not care as long as they get the results of reproducing the perfect copy. Each will bear the consequences of natural laws.”

However, Bozov points out that with proper computational technology development and a nanotech setting, one may achieve tissue regeneration by augmenting carbon signaling systems. “Applications of such systems that control information are ultimately generating new forms of technology that can optimize bio-fuel production, sustain environmental impacts, compute aging processes, and provide a novel system for healthcare management, such as cancer inductive forces that outpace expectancy.”

Giuseppe Calamita, an expert in the field of informatics who currently works at the Institute of Plant Genetics in Italy, echoes Bosov’s focus on technology. “As a database user interface developer and web designer, I developed a user interface for accessing, managing, and mining vegetal genetic sequences,” he says. “I see two main issues: how to develop new findings and how to make them accessible to the scientific community. These issues are about ontology and informatics.”

What do you think? If you have a question or comment about the DNA/RNA/Cloning sector, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

There is a lot going on in aquaculture

By Maureen Aylward

We have found that Zintro has many experts who are interested in aquaculture and want to share their expertise; after all it is a new and growing field that has its challenges and opportunities. We asked our aquaculture experts about what they think are the critical issues facing the aquaculture industry today and the top solutions that are surfacing to tackle these issues. Here is what they had to say.

Stephen Newman, PhD, a well-known global expert in aquaculture, thinks that aquaculture is the last wave in the shift from hunting to an agricultural paradigm. “It is a complex practice involving hundreds of species in many different ecosystems,” says Newman. “Whether land, ocean or lake, pond, open or closed system, there are many challenges that must be overcome for aquaculture to be sustainable and ensure that humanity will reap the rewards of this source of high quality nutrients”.

Newman defines aquaculture as the cultivation of plants and animals in water, and it has been growing at a phenomenal rate for decades. It has not been without its detractors, and the path upward has not been a consistent process with different species showing significant variability. “While the overall trend is towards increased production, several factors are impacting this progress,” says Newman. He says that there are three primary issues.

  • The first is sustainability. “What this means is a source of considerable debate, but simply put, it means that the practices of today must not diminish the ability of the industry to flourish and meet an ever increasing demand in the future,” says Newman. “Practices that allow environmental damage to occur or diseases to proliferate are not consistent with long-term economic viability and are not sustainable. While there are organizations developing standards that link certification with sustainability, the truth is that what is occurring in the field is not truly sustainable.”
  • The second issue is that some non-governmental organizations (NGOs) criticize aquacultural practices by making generalizations about specific sectors and apply them to the industry as a whole. “In some instances NGOs advise buyers, and buyers may develop unrealistic expectations about the nature of the process and end products,” says Newman.
  • The third issue is disease control. “There is no sustainability without disease control, and when standards fail to adequately deal with these issues, aquaculture practices are not sustainable,” says Newman

Newman says that the solutions to these issues are linked.

Disease management programs: “Certification programs, best aquaculture practices, general accounting procedures, codes of conduct, and so on must take into account the impact of disease and actively require proactive disease management programs that consider all of the elements needed to ensure that disease is not going to impact operations,” says Newman. “China,Vietnam, andIndonesia are currently experiencing serious disease problems, even on certified farms, because of inadequate disease management programs.Thailand, on the other hand, through government programs and a concerted effort on the part of some major players in the industry, is successfully dealing with disease problems.”

Proactive disease management programs are programs must address the underlying causes of disease, not just what is fashionable or immediately relevant. “The best example of this is that companies that routinely stress animals as a common element of cultural practices experience lower survival rates and poorer overall productivity because of it,” points out Newman. “Yet, these companies fail to take the steps needed to improve culture conditions because of cost and the failure of companies that demand certified product to pay more for certified products.”

Disease is normal in any intensive agricultural process and considerable effort must go into proactively managing disease. “When and if the consumer is willing to pay a modest premium for seafood that meets the desired criteria, it will be easier for many aquaculturists to justify the costs of disease prevention programs,” says Newman.

NGOs should focus on real issues: Newman says that Some NGOs that criticize the aquaculture industry claim that the worst case scenarios represent the norm. “Many NGOs still stick to non-issues, such as the use of fish meal and oil in feeds, and try to link this to overfishing and other issues that the facts just do not support,” he says. “Some NGOs are beginning to move toward moderation and perhaps may eventually see that they have a common goal with the producers.”

Certification programs need input: “Most certification programs are flexible enough to evolve with time, provided the proper input is there,” says Newman. “Widespread understanding of the critical role that exportation of seafood plays in many government economies is needed and this will result in tighter regulatory controls that could eventually lead to true sustainability practices.”

Patrick Wood, an expert in the seafood and aquaculture industry, says that aquaculture is a relatively new endeavor in the Western hemisphere. “Getting the right risk-free species that are market successful is important,” he points out. “Salmon, shrimp (vannamei), and tilapia are now domesticated, which helps lessen dependence on external factors and creates a basis for further enhancements.”

Wood says that the major critical issues are the same for any other growth industry: money. In addition, he recognizes the following other issues:

  • Access to funding for capital expenditure, operational costs, trade finance, and seed (larvae) and feed;
  • Suitable species for aquaculture and genetic developments;
  • Disease management;
  • Routes to market; and
  • Innovation and application of new technologies.

Wood says that some potential solutions include the consolidation of businesses to develop the industry and addressing the needs of financing specific to the industry. “Market demand is happening with explosion of Southeast Asia’s middle class that has purchasing power, which includes eating seafood,” says Wood. “Prices are rising and fisheries cannot supply shortfall and capital needs to flow into the industry.”

Bill Manci, a consultant that specializes in aquaculture and fish farming projects, says that most of the fish and seafood that we directly consume today is now produced at aquaculture facilities. “Aquaculture faces some important challenges, but the most pressing are the cost of feeds, the ability to manage disease, and the availability of water and land for aquaculture production and expansion,” he says. “Aquaculture is how the majority of our fish will be produced in the future, saving wild populations from overexploitation.”

Manci points out that in many cases, feeds are the most expensive cost component in aquaculture, primarily because of raw materials costs, such as fish meal and fish oil. “Governments and private scientists are developing alternatives to fish meal and fish oil at lower cost and preparing them in facilities that are more biosecure than could ever be expected from the wild populations of fish used to produce these products,” says Manci.

Manci says that rather than fighting disease episodes with antibiotics, which can linger and potentially harm people and the environment, aquaculture managers are using probiotics (i.e., beneficial bacteria), vaccines, and benign compounds that stimulate fish immune systems. “Probiotics crowd out disease-causing organisms and promote good health. Vaccines prevent infection and immunostimulants allow fish to manage their own health,” Manci says.

“As water and land become scarcer and more valuable, aquaculturists have taken steps to make facilities smaller and more efficient,” explains Manci. “Re-circulating aquaculture systems grow fish at high densities and require less space and water to operate. Fish are reared in tanks and in water that is used, filtered to remove wastes and replenish oxygen, and then reused by the fish. In some cases, the wastewater from these systems is directed into greenhouses for the production of flavorful lettuce, tomatoes, and vegetables and flowers. This process called aquaponics is very popular and facilitates production in compact facilities near major markets, producing locally grown food.”

What do you think? If you have a question or comment about the aquaculture industry, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

Microfinance: Why is it in the hot seat?

By Maureen Aylward

It seems like microfinance has been in the hot seat recently. We asked Zintro experts to explain the key factors behind the questioning.

Sophia Velissaratou, a risk expert and founding member of the Women Advancing Microfinance (WAM) UK chapter, says that due to its high repayment  rates (more than 98 percent) and low risk profile, microfinance is an attractive new asset class for commercial investors. “Funding was pouring in and the sector experienced a rapid growth and competition increased,” explains Velissaratou. “As a result, the focus shifted from clients’ needs to high profitability for the microfinance institutions themselves. Investors wanted their money back sooner rather than later, and something changed in the industry.”

Velissaratou says that the Banana Skins 2011 survey, which was conducted by the Centre for Study of Financial Inclusion, reports that the main concerns within microfinance are credit risk, unethical lending practices, fierce competition and reputational risk. “Worldwide there are numerous microfinance initiatives that use best practices and make a difference in the lives of the poor. However, controversy in microfinance should be a wake-up call for practitioners, donors and investors alike,” says Velissaratou. “There should be more focus on clients and their needs. Microfinance institutions should become more professional with robust risk management but remain flexible and avoid overregulation. In addition, they need to better educate clients about their needs and educate practitioners about their work ethic. Lastly, microfinance needs to be continuously in search of simple and effective solutions and avoid one-size-fits-all quick fixes.”

Patricia Tyre, an expert in microfinance who created a microfinance investment fund for people living in poverty in Southeast Asia, says that she sees several reasons why microfinance is under scrutiny at the moment:

  • Aggressive lending practices brought on by an abundance of lenders,
  • A lack of intimacy with the clients or borrowers, and
  • The dilution of the mission.

“Microfinance was developed as a demonstration of a pure value chain. “Those people who received their resources from working gave to those who needed resources to expand. The result of everyone’s hard work was the free flow of money,” says Tyre. “There wasn’t any need for regulations when the implied contract was in the fundamental understanding of the mission.” Tyre says that the recent economic crisis exposed this pure value chain of financial return to a larger market that wanted to enter microfinance. “In late 2008, when the credit markets seized up, microfinance was nearly the only game in town,” she says. “This left it vulnerable to players with non-mission related agendas. Those new players flooded the markets in places like India, which put pressure on lenders, and a microfinance sub-prime market was created.”

Theo Baken, an expert in microfinance since 1980, says that microfinance has been in the hot seat for many years now. “It operates in a vulnerable environment, and due to its outreach, it has reached levels of sustainability and achieved success,” says Baken. “Microfinance has also become an easy target for finger pointing; however, it should be acknowledged that microfinance represents just one of the elements in poverty reduction.”

Baken says that the growth of the microfinance industry through its outreach to the poor population has captured the attention of politicians in many countries in Africa, Asia, and Latin America. “Politicians are eager to misinterpret common parameters, such as the costs of financial services, and paint it as charging unreasonable and excessive rates of interest,” he says. “Institutions in the financial sector express doubts on the basis of their own risk management policies and handling of securities, and therefore, artificially keep microfinance institutions at arm’s length making microfinance an easy target.”

Nevertheless, the microfinance industry is developing itself in a rigorous manner. “Product development of financial services is increasing through financial inclusion and supports income generation and business development,” says Baken. “Capacity development supports performance, and regulations are stricter than the formal financial sectors.” Baken also points out that the industry sees client protection as a major issue and that bilateral and multilateral agencies contribute to equitable and efficient local markets for microfinance.

What do you think? If you have a question or comment about the microfinance industry, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

Bioinformatics: Inspiration ahead

By Maureen Aylward

We asked our Zintro experts to tell us what they think is the most inspiring and important discoveries coming out of bioinformatics today.

Kenneth Rubenstein , PhD, an executive in vitro diagnostic industry and consultant specializing in dx/bioanalytics for start-ups and emerging companies, says that next-generation DNA sequencing (NGS) technologies have taken the life sciences research world by storm. The first human genome sequence was completed in 2001 after five years and an expenditure of several billion US dollars. Intensive bioinformatics input was essential since tens of thousands of small fragments of DNA were sequenced and assembled into their proper order, explains Rubenstein.

“NGS technologies came on the scene in 2005. Since they produce even smaller sequenced fragments than older methods, bioinformatics for assembly, mapping, and data interpretation have gotten more complex and elaborate,” he says. “Given that tens of thousands of genomes have now been sequenced, the informatics task is shifting toward deriving actionable biological information from sequence data. The human genome and those of other organisms are not well understood in many ways. Indeed, the more we learn the more questions that open up to be addressed.”

Rubenstein says that several companies, notably Ingenuity Systems and a host of academic contributors, are working on ways to link established knowledge bases to new sequence data to provide clues to suggest downstream biological investigations. “Although a great many NGS informatics challenges remain, the main ones center on how to make sense of all this data, especially with regard to cancer applications where ten thousand or more tumor genomes will soon have sequences,” Rubenstein explains.

Ramon-Garcia, PhD, a researcher and expert in cellular and molecular biology of virus infection, says that the most important discoveries in the field of biomedicine are new tools that allow for the interpretation of raw data obtained in next-generation sequencing. However, Garcia sees challenges in the generation of new predictive tools to integrate high-throughput genomic data (gene expression, genome structure, miRNA, gene mutation, and methylation), clinical data, and environmental data to predict outcome or response to treatment for patients.

CompBioExpert, a computational biologist and senior scientist, says that an area of application in bioinformatics that is getting more interesting is the metagenomics of microbial communities, particularly the metagenomics of the human biome (basically what’s living in your gut) and other extreme or important environments. He recommends the recent article in the The New York Times that reports the human biome falls into one of three types of enterotypes, human gut ecosystems.

Paul Shapiro, PhD, an expert in molecular cell biology, molecular biology, and biochemistry, says that important bioinformatics applications continue to be developed to support the staggering pace of developments in genome sequencing hardware, especially for determining human genomic sequence variations (single nucleotide level, large insertions/deletions, duplications/CNVs, in/dels and structural variations). “These are areas that may be associated with disease risk and other phenotypes, most notably pharmacogenomics and for identifying all microbial species in environmental metagenomic samples using culture independent methods,” says Shapiro.

What do you think? If you have a question or comment about the bioinformatics field, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

Microsoft and Skype join forces

By Maureen Aylward

With the big news coming out last week that Microsoft is set to purchase Skype for $8.5 billion, we wanted to know from our M&A Zintro experts what they think about the acquisition and if it will change anything for Skype’s 170 million global users.

SeanJC, an IT strategist with an expertise in internet-based applications, thinks that the deal will strengthen the position of Microsoft as it has become an out-dated internet company. “I feel that Microsoft has not moved with the internet and has been over taken by Google, Facebook, and others,” he says. “This is proven by the complete SEO change of Microsoft in launching the Bing search engine.” The purchase of Skype is a huge benefit for Microsoft. “I think that the purchase of a company that is not making a profit – for such a high purchase price –  can  only mean that Microsoft will look to capitalize on this purchase,” says SeanJC. “This will mean that Skype may be integrated into the Windows environment, both platform and mobile, and the possibility of a license- or advertising-based revenue stream using Skype, which may involve cutting back or limiting free Skype calls.” SeanJC goes on to say that the buying of Skype will secure Microsoft’s position, allow it to play a bigger part in the online world, and restore the dominance it once held in the computer world in general.

Jack Worthington, a global private equity investment and management managing partner, says that Microsoft’s acquisition of Skype and its development of Bing are portfolio covering moves, clear examples that the Microsoft executives are looking to Google for thought leadership on the future of the infotech industry. “In my opinion, a future battlefield will be online software applications, where again, Google leads,” statesWorthington “I am looking at what this unfolding corporate chess game tells us about the two organizations. However, it’s clear which company leads and which one follows.”

What do you think? If you have a question or comment about the online software industry, we would like to hear it. Click here. Would you be interested in signing up to be a Zintro expert and generate free leads for your business? Click here.

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